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chloramphenicol can easily pass deeply through cell membranes to inactivate bacteria living within, and into organs where other antibiotics cannot.
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other agents with in vitro activity suggested for use in conjunction with ciprofloxacin or doxycycline include rifampin, vancomycin, imipenem, chloramphenicol, penicillin and ampicillin, clindamycin, and clarithromycin; but other than for penicillin, limited or no data exist regarding the use of these agents in the treatment of inhalational b.
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despite the small proportion of unchanged drug excreted in the urine, the concentration of free chloramphenicol is relatively high, amounting to several hundred mcg ml in patients receiving divided doses of 50 mg kg day.
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